The effects of single-dose atenolol, labetalol, and propranolol on cardiac and vascular function

Jordan L. Holtzman, Denise Finley, Bradford Johnson, Donald A. Berry, Mark A. Sirgo

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The pharmacodynamic effects of single oral doses of atenolol (100 mg), labetalol (300 mg), and propranolol (80 mg) were compared with those of placebo in a randomized, double-blind, Latin square design in 12 patients with hypertension. Atenolol and propranolol both significantly reduced cardiac output (-0.55 vs. -0.31 L/min) and heart rate (-8.0 vs. -6.6 bpm), whereas labetalol had no effect on either parameter (-0.08 L/min; + 1.0 bpm). Labetalol significantly reduced vascular resistance (-339 dynes · cm/sec5), but atenolol and propranolol did not (147 vs. 62 dynes · cm/sec5). Only labetalol significantly reduced the systolic (-15.3 mm Hg), diastolic (-11.5 mm Hg), and mean blood pressures (-12.8 mm Hg). Atenolol significantly reduced only diastolic blood pressure (-5.20 mm Hg), whereas propranolol failed to lower these parameters significantly. These data indicate that the hemodynamic profile of labetalol differs from that of selective and nonselective β-blockers. Labetalol lowered blood pressure primarily by reducing vascular resistance, whereas reductions in heart rate and cardiac output were the predominant effects of atenolol and propranolol.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalClinical pharmacology and therapeutics
Volume40
Issue number3
DOIs
StatePublished - Sep 1986

Fingerprint Dive into the research topics of 'The effects of single-dose atenolol, labetalol, and propranolol on cardiac and vascular function'. Together they form a unique fingerprint.

Cite this