The emerging role of TH17 cells in organ transplantation

Jeremy A. Sullivan; Andrew B. Adams; William J. Burlingham

doi:10.1097/TP.0000000000000000

The emerging role of TH17 cells in organ transplantation

Jeremy A. Sullivan, Andrew B. Adams, William J. Burlingham

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression.

Original language	English (US)
Pages (from-to)	483-489
Number of pages	7
Journal	Transplantation
Volume	97
Issue number	5
DOIs	https://doi.org/10.1097/TP.0000000000000000
State	Published - Mar 15 2014
Externally published	Yes

Keywords

Collagen type V
IL-23
Monocytes
P2X7
TH17
Transplantation

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title = "The emerging role of TH17 cells in organ transplantation",

abstract = "While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression.",

keywords = "Collagen type V, IL-23, Monocytes, P2X7, TH17, Transplantation",

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AU - Adams, Andrew B.

AU - Burlingham, William J.

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N2 - While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression.

AB - While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression.

KW - Collagen type V

KW - IL-23

KW - Monocytes

KW - P2X7

KW - TH17

KW - Transplantation

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VL - 97

SP - 483

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JO - Transplantation

JF - Transplantation

IS - 5

ER -

The emerging role of TH17 cells in organ transplantation

Abstract

Keywords

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