The enhanced permeability and retention (EPR) effect is the property which small sized nanoparticles and macromolecular drugs can accumulate more in tumor than in normal tissues. The EPR effect is generally due to the larger pore size of neo-vasculatures and poor lymphatic clearance of tumors, and it is strongly influenced by the size of small molecules including nanoparticles. The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors. Based on the EPR concept, a variety of drugs in nano-carrier systems have been developed for cancer therapy. In this chapter, current progress and good examples for EPR effect-utilized anticancer therapy are reviewed.
|Original language||English (US)|
|Title of host publication||Cancer Targeted Drug Delivery|
|Subtitle of host publication||An Elusive Dream|
|Publisher||Springer New York|
|Number of pages||12|
|ISBN (Print)||1461478758, 9781461478751|
|State||Published - Jul 1 2013|