The ethanol metabolite acetic acid activates mouse nucleus accumbens shell medium spiny neurons

Research output: Contribution to journalArticlepeer-review

Abstract

Although ethanol consumption leads to an array of neurophysiological alterations involving the neural circuits for reward, the underlying mechanisms remain unclear. Acetic acid is a major metabolite of ethanol with high bioactivity and potentially significant pharmacological importance in regulating brain function. Yet, the impact of acetic acid on reward circuit function has not been well explored. Given the rewarding properties associated with ethanol consumption, we investigated the acute effects of ethanol and/or acetic acid on the neurophysiological function of medium spiny neurons of the nucleus accumbens shell, a key node in the mammalian reward circuit. We find that acetic acid, but not ethanol, provided a rapid and robust boost in neuronal excitability at physiologically relevant concentrations, whereas both compounds enhanced glutamatergic synaptic activity. These effects were consistent across both sexes in C57BL/6J mice. Overall, our data suggest acetic acid is a promising candidate mediator for ethanol effects on mood and motivation that deserves further investigation.

Original languageEnglish (US)
Pages (from-to)620-627
Number of pages8
JournalJournal of neurophysiology
Volume125
Issue number2
DOIs
StatePublished - Feb 2021

Bibliographical note

Funding Information:
This study was supported by NIH R01DA041808 and MnDRIVE Neuromodulation Fellowship (A.D.C.).

Publisher Copyright:
© 2021 the American Physiological Society.

Keywords

  • Acetic acid
  • Ethanol
  • Glutamate
  • Nucleus accumbens
  • Short-chain fatty acid

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

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