The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components

Thomas Bradbury; Thomas K. Fehring; Michael Taunton; Arlen Hanssen; Khalid Azzam; Javad Parvizi; Susan M. Odum

doi:10.1016/j.arth.2009.04.028

The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components

Thomas Bradbury, Thomas K. Fehring, Michael Taunton, Arlen Hanssen, Khalid Azzam, Javad Parvizi, Susan M. Odum

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

The success of open irrigation and debridement with component retention (ODCR) for acute periprosthetic knee joint infection varies widely. The species and virulence of the infecting organism have been shown to influence outcome. This multicenter, retrospective study identified 19 cases of acute periprosthetic methicillin-resistant Staphylococcus aureus (MRSA) knee infections managed by ODCR and at least 4 weeks of postoperative intravenous vancomycin therapy. At minimum follow-up of 2 years, the treatment failed to eradicate the infection in 16 cases (84% failure rate). Of those 16 failures, 13 patients required a 2-stage exchange arthroplasty, 2 patients required repeat incision and debridement with antibiotic suppression, and 1 patient died of MRSA sepsis. In addition, a systematic review of the literature revealed failure to eradicate infection in 10 of 13 patients managed with a similar protocol. The total success rate of ODCR in acute periprosthetic MRSA knee infection was 18%.

Original language	English (US)
Pages (from-to)	101-104
Number of pages	4
Journal	Journal of Arthroplasty
Volume	24
Issue number	6 SUPPL.
DOIs	https://doi.org/10.1016/j.arth.2009.04.028
State	Published - Sep 2009
Externally published	Yes

Keywords

MRSA
open debridement
retention of components
TKA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components",

abstract = "The success of open irrigation and debridement with component retention (ODCR) for acute periprosthetic knee joint infection varies widely. The species and virulence of the infecting organism have been shown to influence outcome. This multicenter, retrospective study identified 19 cases of acute periprosthetic methicillin-resistant Staphylococcus aureus (MRSA) knee infections managed by ODCR and at least 4 weeks of postoperative intravenous vancomycin therapy. At minimum follow-up of 2 years, the treatment failed to eradicate the infection in 16 cases (84% failure rate). Of those 16 failures, 13 patients required a 2-stage exchange arthroplasty, 2 patients required repeat incision and debridement with antibiotic suppression, and 1 patient died of MRSA sepsis. In addition, a systematic review of the literature revealed failure to eradicate infection in 10 of 13 patients managed with a similar protocol. The total success rate of ODCR in acute periprosthetic MRSA knee infection was 18%.",

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AU - Parvizi, Javad

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The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components

Abstract

Keywords

UN SDGs

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