The first direct ammonolysis of 2-thiouracil nucleosides to 2- thiocytosine nucleosides

Lucjan Strekowski, Ibrahim M. Abdou, Adel M.E. Attia, Steven Patterson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Sugar-peracetylated 1-(β-D-glucopyranosyl)-, 1-(β-D-galactopyranosyl)-, and 1-(β-D-xylopyranosyl)-6-aryl-5-cyano-2-thiouracils 2-4 and the corresponding 1-pyranosyl-2-(pyranosylthio)pyrimidines 5-7 undergo efficient ammonolysis (NH3/MeOH, 0→23°C, 16 h) to give the corresponding 1-(β-D- pyranosyl)-6-aryl-5-cyano-2-thiocytosines.

Original languageEnglish (US)
Pages (from-to)4757-4761
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number24
DOIs
StatePublished - Jun 10 2000

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • 1-(β-D-pyranosyl)-2-thiocytosines
  • 6-aryl-5-cyano-2-thiouracils

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