Abstract
Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resulted in the formation of a cyclic carbonate. Its taxol and taxotere analogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.
Original language | English (US) |
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Pages (from-to) | 1831-1834 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 4 |
Issue number | 15 |
DOIs | |
State | Published - Aug 11 1994 |