TY - JOUR
T1 - The fourth way? Harnessing aggressive tendencies in the thymus
AU - Baldwin, Troy A.
AU - Kristin, A.
AU - Hogquist,
AU - Jameson, Stephen C.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - During late stages of thymic development, T cells must chose between different fates, dictated by their TCR specificity. Typically, this is thought of as a choice between three alternatives (being positive selection for useful T cells vs negative selection or neglect for harmful or useless T cells). However, there is growing evidence for a fourth alternative, in which T cells are positively selected by agonist ligands, which would normally be expected to induce T cell deletion. In this review, we will discuss where and when agonist selection is induced and whether this should be considered as a novel form ofthymic selection or as an alternative differentiation state for Ag-exposed T cells.
AB - During late stages of thymic development, T cells must chose between different fates, dictated by their TCR specificity. Typically, this is thought of as a choice between three alternatives (being positive selection for useful T cells vs negative selection or neglect for harmful or useless T cells). However, there is growing evidence for a fourth alternative, in which T cells are positively selected by agonist ligands, which would normally be expected to induce T cell deletion. In this review, we will discuss where and when agonist selection is induced and whether this should be considered as a novel form ofthymic selection or as an alternative differentiation state for Ag-exposed T cells.
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U2 - 10.4049/jimmunol.173.11.6515
DO - 10.4049/jimmunol.173.11.6515
M3 - Short survey
C2 - 15557139
AN - SCOPUS:9144259224
SN - 0022-1767
VL - 173
SP - 6515
EP - 6520
JO - Journal of Immunology
JF - Journal of Immunology
IS - 11
ER -