The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization

Christina A. Cuomo, Ulrich Güldener, Jin Rong Xu, Frances Trail, B. Gillian Turgeon, Antonio Di Pietro, Jonathan D. Walton, Li Jun Ma, Scott E. Baker, Martijn Rep, Gerhard Adam, John Antoniw, Thomas Baldwin, Sarah Calvo, Yueh Long Chang, David DeCaprio, Liane R. Gale, Sante Gnerre, Rubella S. Goswami, Kim Hammond-KosackLinda J. Harris, Karen Hilburn, John C. Kennell, Scott Kroken, Jon K. Magnuson, Gertrud Mannhaupt, Evan Mauceli, Hans Werner Mewes, Rudolf Mitterbauer, Gary Muehlbauer, Martin Münsterkötter, David Nelson, Kerry O'Donnell, Thérèse Ouellet, Weihong Qi, Hadi Quesneville, M. Isabel G Roncero, Kye Yong Seong, Igor V. Tetko, Martin Urban, Cees Waalwijk, Todd J. Ward, Jiqiang Yao, Bruce W. Birren, H. Corby Kistler

Research output: Contribution to journalArticlepeer-review

565 Scopus citations

Abstract

We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.

Original languageEnglish (US)
Pages (from-to)1400-1402
Number of pages3
JournalScience
Volume317
Issue number5843
DOIs
StatePublished - Sep 7 2007

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