The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

G. Krapivinsky, E. A. Gordon, K. Wickman, B. Velimirović, L. Krapivinsky, D. E. Clapham

Research output: Contribution to journalArticlepeer-review

722 Scopus citations


Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K +-channel gene, GIRK1, alone encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
Issue number6518
StatePublished - Jan 1 1995

Fingerprint Dive into the research topics of 'The G-protein-gated atrial K<sup>+</sup> channel I<sub>KAch</sub> is a heteromultimer of two inwardly rectifying K<sup>+</sup>-channel proteins'. Together they form a unique fingerprint.

Cite this