The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

G. Krapivinsky; E. A. Gordon; K. Wickman; B. Velimirović; L. Krapivinsky; D. E. Clapham

doi:10.1038/374135a0

The G-protein-gated atrial K⁺ channel I_KAch is a heteromultimer of two inwardly rectifying K⁺-channel proteins

G. Krapivinsky, E. A. Gordon, K. Wickman, B. Velimirović, L. Krapivinsky, D. E. Clapham

Pharmacology

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Abstract

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K⁺) channel, I_KACh. Activated muscarinic receptors stimulate l_KAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K ⁺-channel gene, GIRK1, alone encodes I_KAch-It is now shown that I_KAch is a heteromultimer of two distinct inwardly rectifying K⁺-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

Original language	English (US)
Pages (from-to)	135-141
Number of pages	7
Journal	Nature
Volume	374
Issue number	6518
DOIs	https://doi.org/10.1038/374135a0
State	Published - 1995

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title = "The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins",

abstract = "Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K +-channel gene, GIRK1, alone encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.",

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AU - Krapivinsky, G.

AU - Gordon, E. A.

AU - Wickman, K.

AU - Velimirović, B.

AU - Krapivinsky, L.

AU - Clapham, D. E.

PY - 1995

Y1 - 1995

N2 - Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K +-channel gene, GIRK1, alone encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

AB - Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K +-channel gene, GIRK1, alone encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

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ER -

The G-protein-gated atrial K⁺ channel I_KAch is a heteromultimer of two inwardly rectifying K⁺-channel proteins

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