The gene for murine CTP: Phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16

Mark S. Rutherford; Charles O. Rock; Nancy A. Jenkins; Debra J. Gilbert; Teresa G. Tessner; Neal G. Copeland; Suzanne Jackowski

doi:10.1016/S0888-7543(05)80377-5

The gene for murine CTP: Phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16

Mark S. Rutherford, Charles O. Rock, Nancy A. Jenkins, Debra J. Gilbert, Teresa G. Tessner, Neal G. Copeland, Suzanne Jackowski

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Abstract

CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J × Mus spretus)F₁ × C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.

Original language	English (US)
Pages (from-to)	698-701
Number of pages	4
Journal	Genomics
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/S0888-7543(05)80377-5
State	Published - Dec 1993

Bibliographical note

Funding Information:
We thank M. Barnstead for excellent technical assistance. This work was supported by National Institutes of Health Grant GM45737 from the National Institute of General Medical Sciences, National Research Service Award T32 CA09346 from the National Cancer Institute (to T.G.T.), Cancer Center (CORE) Grant CA21765 from the National Cancer Institute, the American Lebanese Syrian Associated Charities, and the National Cancer Institute, DHHS, under Contract NO1-CO-74101 with ABL.

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title = "The gene for murine CTP: Phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16",

abstract = "CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J × Mus spretus)F1 × C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.",

author = "Rutherford, {Mark S.} and Rock, {Charles O.} and Jenkins, {Nancy A.} and Gilbert, {Debra J.} and Tessner, {Teresa G.} and Copeland, {Neal G.} and Suzanne Jackowski",

note = "Funding Information: We thank M. Barnstead for excellent technical assistance. This work was supported by National Institutes of Health Grant GM45737 from the National Institute of General Medical Sciences, National Research Service Award T32 CA09346 from the National Cancer Institute (to T.G.T.), Cancer Center (CORE) Grant CA21765 from the National Cancer Institute, the American Lebanese Syrian Associated Charities, and the National Cancer Institute, DHHS, under Contract NO1-CO-74101 with ABL.",

year = "1993",

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doi = "10.1016/S0888-7543(05)80377-5",

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journal = "Genomics",

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T2 - Phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16

AU - Rutherford, Mark S.

AU - Rock, Charles O.

AU - Jenkins, Nancy A.

AU - Gilbert, Debra J.

AU - Tessner, Teresa G.

AU - Copeland, Neal G.

AU - Jackowski, Suzanne

N1 - Funding Information: We thank M. Barnstead for excellent technical assistance. This work was supported by National Institutes of Health Grant GM45737 from the National Institute of General Medical Sciences, National Research Service Award T32 CA09346 from the National Cancer Institute (to T.G.T.), Cancer Center (CORE) Grant CA21765 from the National Cancer Institute, the American Lebanese Syrian Associated Charities, and the National Cancer Institute, DHHS, under Contract NO1-CO-74101 with ABL.

PY - 1993/12

Y1 - 1993/12

N2 - CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J × Mus spretus)F1 × C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.

AB - CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J × Mus spretus)F1 × C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.

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The gene for murine CTP: Phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16

Abstract

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