The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

Harry T. Orr; Doron Lancet; Richard J. Robb; José A.Lopez De Castro; Jack L. Strominger

doi:10.1038/282266a0

The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

Harry T. Orr, Doron Lancet, Richard J. Robb, José A.Lopez De Castro, Jack L. Strominger

Laboratory Medicine and Pathology

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Abstract

The 88-residue fragment (ac-2) containing the second disulphide loop from HLA-B7 heavy chain is shown to have statistically significant homology with Ig constant domains, including both matches at invariant positions and conservative substitutions of structurally important residues. Thus, both the light chain (β₂m) and a segment of the heavy chain of HLA antigens may be structurally and evolutionarily related to immunoglobulins.

Original language	English (US)
Pages (from-to)	266-270
Number of pages	5
Journal	Nature
Volume	282
Issue number	5736
DOIs	https://doi.org/10.1038/282266a0
State	Published - 1979

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AU - Lancet, Doron

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AU - De Castro, José A.Lopez

AU - Strominger, Jack L.

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The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

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