The hypothalamic-pituitary-adrenal axis and viral infection

Michael Bailey; Harald Engler; John Hunzeker; John F. Sheridan

doi:10.1089/088282403322017884

The hypothalamic-pituitary-adrenal axis and viral infection

Michael Bailey, Harald Engler, John Hunzeker, John F. Sheridan

Genetics, Cell Biology and Development (TMED)

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis plays an important immunomodulatory role during viral infection. Activation of the HPA axis ultimately leads to elevated plasma levels of glucocorticoid (GC) hormones with the ability to mediate adaptive behavioral, metabolic, cardiovascular and immune system effects. In this review, we focus on the modulation of anti-viral immunity and viral pathogenesis by the HPA axis.

Original language	English (US)
Pages (from-to)	141-157
Number of pages	17
Journal	Viral Immunology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1089/088282403322017884
State	Published - 2003

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The hypothalamic-pituitary-adrenal axis and viral infection

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