The impact of symptomatic knee osteoarthritis on overall gait pattern deviations and its association with performance-based measures and patient-reported outcomes

Josefine E. Naili, Anna Clara Esbjörnsson, Maura D. Iversen, Michael H. Schwartz, Margareta Hedström, Charlotte K. Häger, Eva W. Broström

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background Limited knowledge exists regarding the impact of symptomatic knee osteoarthritis (OA) on the overall gait pattern; and whether gait deviations are associated with performance-based measures (PBMs) and patient-reported outcomes (PROs). This cross-sectional study evaluated overall gait patterns in patients with knee OA using the Gait Deviation Index for kinematics (GDI) and kinetics (GDI-kinetic), and explored associations between gait deviations, PBMs, and PROs. Methods Forty patients with knee OA and 25 age and gender-matched controls underwent three-dimensional gait analysis. Participants performed the Timed Up and Go (TUG), Five Times Sit-to-Stand (5STS), and Single Limb Mini Squat (SLMS) tests and completed a disease-specific PRO. Associations between gait deviations, PBMs, and PROs were assessed by Pearson's correlation and multiple linear regression. Results Patients with OA demonstrated significantly lower GDI and GDI-kinetic scores of the OA and contralateral limbs compared to controls; with GDI-kinetic scores on the contralateral limb more impacted than the OA limb. On the contralateral limb, GDI-kinetic score significantly correlated with TUG (r = − 0.42) and 5STS (r = − 0.33), while on the OA limb with TUG (r = − 0.68), 5STS (r = − 0.38), SLMS (r = − 0.38), activities of daily living (r = 0.35) and Knee-related Quality of Life (r = 0.35). No significant associations existed between kinematic GDI scores, PBMs and PROs. Conclusion The overall gait pattern, as represented by GDI and GDI-kinetic scores, in patients with symptomatic knee OA is affected both on the painful OA limb and the contralateral limb. The GDI and GDI-kinetic scores provide different information regarding function that is not revealed by PBMs or PROs.

Original languageEnglish (US)
Pages (from-to)536-546
Number of pages11
JournalKnee
Volume24
Issue number3
DOIs
StatePublished - Jun 2017

Bibliographical note

Funding Information:
This study was supported by grants from Karolinska Institutet , Promobilia , the Swedish Rheumatism Foundation , and the Developmental foundation of the footwear industry . Study sponsors had no involvement in study design, collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.

Funding Information:
This study was supported by grants from Karolinska Institutet, Promobilia, the Swedish Rheumatism Foundation, and the Developmental foundation of the footwear industry. Study sponsors had no involvement in study design, collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

  • Biomechanics
  • Function
  • Gait
  • Osteoarthritis
  • Outcome measures

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