Abstract
Recently we have demonstrated the induction of allogeneic murine cytolytic T lymphocytes (CTL)3 using purified plasma membranes rather than intact cells as stimulatory agents. In this report we extend the use of such subcellular preparations to study the requirements for hapten-specific syngeneic CTL induction. Membranes prepared from trinitrophenyl (TNP) coupled syngeneic tumor cells retain the ability to stimulate both a primary and secondary CTL response. The CTL that are generated are restricted in their lysis to target cells bearing the same H-2 antigens as those present on the TNP-coupled stimulating membranes.
Original language | English (US) |
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Pages (from-to) | 501-502 |
Number of pages | 2 |
Journal | Journal of Immunology |
Volume | 123 |
Issue number | 1 |
State | Published - Dec 1 1979 |