The influence of serum albumin and α1-acid glycoprotein on vancomycin protein binding in patients with burn injuries

Humphrey Z. Zokufa, Lynn D. Solem, Keith A. Rodvold, Kent B. Crossley, J. H. Fischer, John C. Rotschafer

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Ten patients with burn injuries (mean total body surface area burn = 29% ± 16%) were studied at various points in the course of their burn therapy. α1-Acid glycoprotein, albumin, and vancomycin concentrations were determined with either a trough or peak vancomycin quantitative determination. α1-Acid glycoprotein concentrations ranged from 125 to 333 mg/dl and albumin concentrations ranged from 1.7 to 4.2 gm/dl. Vancomycin protein binding, as determined by ultrafiltration, averaged 29% ± 6%. There was a strong (r = 0.92) relationship between percent protein-bound vancomycin and albumin. There was a poor statistical relationship between percent protein-bound vancomycin and α1-acid glycoprotein (r = 0.28). α1-Acid glycoprotein appeared to have virtually no effect on the protein-binding characteristics of vancomycin over the range of concentrations studied.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume10
Issue number5
DOIs
StatePublished - Jan 1 1989

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