T cells function locally. Accordingly, T cells' recognition of antigen, their subsequent activation and differentiation, and their role in the processes of infection control, tumour eradication, autoimmunity, allergy and alloreactivity are intrinsically coupled with migration. Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current paradigms. Here, we review classic and emerging concepts, highlight the challenge of integrating new observations with existing T cell classification schemes and summarize the heuristic framework provided by viewing T cell differentiation and function first through the prism of migration.
Bibliographical noteFunding Information:
The authors thank V. Vezys and S. Jameson (University of Minnesota) for helpful discussion. This study was supported by US National Institutes of Health (NIH) grant R01AI084913‑01 (to D.M.), NIH grant T32AI007313 (to J.M.S.) and the Office Of The Director, NIH, under Award Number DP2OD006467 (to D.M.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.