Event-Related Potentials were recorded over occipital and parietal scalp from left- and right-handed adults presented with a language and a non-language visual stimulus using a divided field, "oddball" paradigm. The major finding of interest was that the P300 component was larger over the left than the right hemisphere of the right-handers when the language stimulus was presented to the left hemisphere; there were no hemispheric differences for the left-handers, regardless of field of presentation. These results are discussed in the context of developing noninvasive measures to lateralize language function.
Bibliographical noteFunding Information:
Research and manuscript preparation were supported by grants to the first author from NIH (HD23389) and the McKnight-Land Grant Endowment of the University of Minnesota; a training grant from NIH (HDO7151) to the Center for Research in Learning, Perception, and Cognition, University of Minnesota; and an award from the Joseph P. Kennedy Foundation. The authors extend their gratitude to the subjects who participated in the study, to Kathy Nugent and Mary Henschel for data collection and tabulation, to Marie Barnich for permission to use her handedness questionnaire, to Kim Pearson for programming, to Merv Bergman for technical assistance, to Dennis Molfese and Emanuel Donchin for statistical advice, and to Drs. John Gates, 110 Leppik, and Robert Gumnit and Michele Kunzi (Minnesota Comprehensive Epilepsy Program) for their assistance in subject recruitment and research support. Reprint requests should be addressed to Charles A. Nelson, Center for Research in Learning, Perception, and Cognition, University of Minnesota, 75 East River Road, Minneapolis, MN 55455.