TY - JOUR
T1 - The long-term outcomes of radiosurgery for intracranial hemangioblastomas
AU - Hanakita, Shunya
AU - Koga, Tomoyuki
AU - Shin, Masahiro
AU - Takayanagi, Shunsaku
AU - Mukasa, Akitake
AU - Tago, Masao
AU - Igaki, Hiroshi
AU - Saito, Nobuhito
PY - 2014/3
Y1 - 2014/3
N2 - BackgroundOptimal timing in the treatment of intracranial hemangioblastoma (HB) remains controversial, particularly for patients of von Hippel-Lindau disease (VHL) with multiple small lesions. We evaluated efficacy of stereotactic radiosurgery (SRS) for intracranial HB based on the longer follow-up data with a larger number of patients and lesions.MethodsTwenty-one patients (11 men, 10 women) initially underwent SRS for 57 intracranial HBs. Seven patients had sporadic lesions and 14 had VHL-related lesions. During the follow-up, 40 lesions were additionally treated in VHL patients in 10 SRS treatments. Thus, a total of 97 lesions were included in this study. Median tumor volume was 0.13 cm3 (range, 0.004-9.5 cm3), and median margin dose was 18 Gy (range, 14-20 Gy).ResultsMedian duration of follow-up was 96 months (range, 3-235 mo) after initial SRS treatment. Ten tumors in 7 patients showed progression after SRS. Actuarial tumor control rates after SRS at 5 and 10 years were 94% and 80%, respectively. Factors associated with longer control were solid lesion (P =. 03), smaller volume (P =. 01), and lesions associated with VHL (P =. 0005) in univariate analysis. Five-and 10-year tumor control rates were 67% and 44% for sporadic patients and 97% and 83% for VHL patients.ConclusionSRS could be offered as an effective treatment for small, solid, and VHL-associated HBs. If the tumors show apparent enlargement in size or can possibly become symptomatic along with a slight increase in size, SRS should be recommended before they present with the clinical symptoms.
AB - BackgroundOptimal timing in the treatment of intracranial hemangioblastoma (HB) remains controversial, particularly for patients of von Hippel-Lindau disease (VHL) with multiple small lesions. We evaluated efficacy of stereotactic radiosurgery (SRS) for intracranial HB based on the longer follow-up data with a larger number of patients and lesions.MethodsTwenty-one patients (11 men, 10 women) initially underwent SRS for 57 intracranial HBs. Seven patients had sporadic lesions and 14 had VHL-related lesions. During the follow-up, 40 lesions were additionally treated in VHL patients in 10 SRS treatments. Thus, a total of 97 lesions were included in this study. Median tumor volume was 0.13 cm3 (range, 0.004-9.5 cm3), and median margin dose was 18 Gy (range, 14-20 Gy).ResultsMedian duration of follow-up was 96 months (range, 3-235 mo) after initial SRS treatment. Ten tumors in 7 patients showed progression after SRS. Actuarial tumor control rates after SRS at 5 and 10 years were 94% and 80%, respectively. Factors associated with longer control were solid lesion (P =. 03), smaller volume (P =. 01), and lesions associated with VHL (P =. 0005) in univariate analysis. Five-and 10-year tumor control rates were 67% and 44% for sporadic patients and 97% and 83% for VHL patients.ConclusionSRS could be offered as an effective treatment for small, solid, and VHL-associated HBs. If the tumors show apparent enlargement in size or can possibly become symptomatic along with a slight increase in size, SRS should be recommended before they present with the clinical symptoms.
KW - gamma knife surgery
KW - intracranial hemangioblastomas
KW - stereotactic radiosurgery
KW - von Hippel-Lindau disease
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U2 - 10.1093/neuonc/not201
DO - 10.1093/neuonc/not201
M3 - Article
C2 - 24335701
AN - SCOPUS:84894225742
SN - 1522-8517
VL - 16
SP - 429
EP - 433
JO - Neuro-Oncology
JF - Neuro-Oncology
IS - 3
ER -