Intracellular fatty acid-binding proteins associate with fatty acids and other hydrophobic biomolecules in an internal cavity, providing for solubilization and metabolic trafficking. Analyses of their in vivo function by molecular and genetic techniques reveal specific function(s) that fatty acid-binding proteins perform with respect to fatty acid uptake, oxidation and overall metabolic homeostasis.
Bibliographical noteFunding Information:
We thank members of the Bernlohr laboratory for helpful suggestions and comments during the preparation of this manuscript. This work was supported by grants NSF 9816575, NIH DK 53189 and NRSA 1 F32 DK09599-01.