While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.
Bibliographical noteFunding Information:
We thank E. Mandelkow for helpful comments, G. Howard and S. Ordway for editorial review, J. Carroll and G. Maki for preparation of graphics, and M. Dela Cruz and E. Loeschinger for administrative assistance. The study was supported by grants from the NIH (AG011385 and NS041787) and the Tau Consortium (to L.M.).