The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Jennifer L. Dearborn; David Knopman; A. Richey Sharrett; Andrea L C Schneider; Clifford R. Jack; Laura H. Coker; Alvaro Alonso; Elizabeth Selvin; Thomas H. Mosley; Lynne E. Wagenknecht; Beverly G. Windham; Rebecca F. Gottesman

doi:10.1159/000362265

The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Jennifer L. Dearborn, David Knopman, A. Richey Sharrett, Andrea L C Schneider, Clifford R. Jack, Laura H. Coker, Alvaro Alonso, Elizabeth Selvin, Thomas H. Mosley, Lynne E. Wagenknecht, Beverly G. Windham, Rebecca F. Gottesman

Epidemiology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).

Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).

Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.

Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.

Original language	English (US)
Pages (from-to)	337-346
Number of pages	10
Journal	Dementia and Geriatric Cognitive Disorders
Volume	38
DOIs	https://doi.org/10.1159/000362265
State	Published - Nov 7 2014

Bibliographical note

Publisher Copyright:
© 2014 S. Karger AG, Basel.

Keywords

Cognition
Cognitive decline
Dementia
Hypertension
Metabolic syndrome
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Dearborn, J. L., Knopman, D., Sharrett, A. R., Schneider, A. L. C., Jack, C. R., Coker, L. H., Alonso, A., Selvin, E., Mosley, T. H., Wagenknecht, L. E., Windham, B. G., & Gottesman, R. F. (2014). The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC). Dementia and Geriatric Cognitive Disorders, 38, 337-346. https://doi.org/10.1159/000362265

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abstract = "Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.",

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doi = "10.1159/000362265",

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AU - Dearborn, Jennifer L.

AU - Knopman, David

AU - Sharrett, A. Richey

AU - Schneider, Andrea L C

AU - Jack, Clifford R.

AU - Coker, Laura H.

AU - Alonso, Alvaro

AU - Selvin, Elizabeth

AU - Mosley, Thomas H.

AU - Wagenknecht, Lynne E.

AU - Windham, Beverly G.

AU - Gottesman, Rebecca F.

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AB - Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.

KW - Cognition

KW - Cognitive decline

KW - Dementia

KW - Hypertension

KW - Metabolic syndrome

KW - Obesity

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The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Abstract

Bibliographical note

Keywords

UN SDGs

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