TY - JOUR
T1 - The molecular repertoire of the 'almighty' stem cell
AU - Eckfeldt, Craig E.
AU - Mendenhall, Eric M.
AU - Verfaillie, Catherine M.
PY - 2005/9
Y1 - 2005/9
N2 - Stem cells share the defining characteristics of self-renewal, which maintains or expands the stem-cell pool, and multi-lineage differentiation, which generates and regenerates tissues. Stem-cell self-renewal and differentiation are influenced by the convergence of intrinsic cellular signals and extrinsic microenvironmental cues from the surrounding stem-cell niche, but the specific signals involved are poorly understood. Recently, several studies have sought to identify the genetic mechanisms that underlie the stem-cell phenotype. Such a molecular road map of stem-cell function should lead to an understanding of the true potential of stem cells.
AB - Stem cells share the defining characteristics of self-renewal, which maintains or expands the stem-cell pool, and multi-lineage differentiation, which generates and regenerates tissues. Stem-cell self-renewal and differentiation are influenced by the convergence of intrinsic cellular signals and extrinsic microenvironmental cues from the surrounding stem-cell niche, but the specific signals involved are poorly understood. Recently, several studies have sought to identify the genetic mechanisms that underlie the stem-cell phenotype. Such a molecular road map of stem-cell function should lead to an understanding of the true potential of stem cells.
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U2 - 10.1038/nrm1713
DO - 10.1038/nrm1713
M3 - Review article
C2 - 16103873
AN - SCOPUS:27744520358
SN - 1471-0072
VL - 6
SP - 726
EP - 737
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 9
ER -