The nature of spatiotemporal changes in cerebral hemodynamics as manifested in functional magnetic resonance imaging

Partha P. Mitra, Seiji Ogawa, Xiaoping Hu, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

The nature of changes in rapidly acquired magnetic resonance images of the brain was studied by using a denoising method and spectral techniques optimally suited to short time series. It was found that the stimulus related changes have a complex epatiotemporal structure even for simple visual stimuli. Apart from a low frequency window, the non-stimulus-related changes were found to correspond in detail to either breathing or heartbeat, although these two sources show different patterns of spatial coherence in the image. At low frequencies, oscillations with frequencies around 0.1 Hz were observed, also with nontrivial space-time structure, which are likely to be vasomotor in origin.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalMagnetic resonance in medicine
Volume37
Issue number4
DOIs
StatePublished - Apr 1997

Keywords

  • denoising
  • multitaper methods
  • singular value decomposition
  • vasomotion

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