Abstract
CHM-1 [2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one] is a quinolone derivative that has been reported to induce apoptosis and inhibit invasion of cancer cells. However, there is no available information to address the effects of CHM-1 on leukemia cells invivo. Therefore, the present study examined the effects of CHM-1 using a mouse model of leukemia. We established leukemia in mice by injecting WEHI-3 cells into BALB/c mice. Mice were then treated with or without CHM-1 (5 and 10 mg/kg). CHM-1 promoted the total survival rate of leukemic mice and these effects were dose-dependent. CHM-1 increased body weight and decreased spleen weight, but did not affect liver weight. The levels of cell markers Mac-3 and CD11b were reduced by CHM-1, indicating that the differentiation of macrophage precursor cells was inhibited. Levels of CD3 and CD19 were induced by CHM-1, suggesting that the differentiation of precursors of T and B cells was promoted in PBMC. Results of the present study indicate that CHM-1 has an inhibitory effect on leukemia induced in mice invivo and warrants further study as to the mechanisms and effects in other types of cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2098-2102 |
| Number of pages | 5 |
| Journal | Leukemia and Lymphoma |
| Volume | 51 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2010 |
Bibliographical note
Funding Information:Declaration of interest: This work was supported by grant DOH99-TD-C-111-005 from Department of Health, Executive Yuan, R.O.C. (Taiwan).
Keywords
- CHM-1
- Invivo
- leukemia WEHI-3 cells
- leukemia murine model
