The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo

Tung Yuan Lai, Jai Sing Yang, Ping Ping Wu, Wen Wen Huang, Sheng Chu Kuo, Chia Yu Ma, W. Gibson Wood, Jing Gung Chung

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7 Scopus citations

Abstract

CHM-1 [2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one] is a quinolone derivative that has been reported to induce apoptosis and inhibit invasion of cancer cells. However, there is no available information to address the effects of CHM-1 on leukemia cells invivo. Therefore, the present study examined the effects of CHM-1 using a mouse model of leukemia. We established leukemia in mice by injecting WEHI-3 cells into BALB/c mice. Mice were then treated with or without CHM-1 (5 and 10 mg/kg). CHM-1 promoted the total survival rate of leukemic mice and these effects were dose-dependent. CHM-1 increased body weight and decreased spleen weight, but did not affect liver weight. The levels of cell markers Mac-3 and CD11b were reduced by CHM-1, indicating that the differentiation of macrophage precursor cells was inhibited. Levels of CD3 and CD19 were induced by CHM-1, suggesting that the differentiation of precursors of T and B cells was promoted in PBMC. Results of the present study indicate that CHM-1 has an inhibitory effect on leukemia induced in mice invivo and warrants further study as to the mechanisms and effects in other types of cancer.

Original languageEnglish (US)
Pages (from-to)2098-2102
Number of pages5
JournalLeukemia and Lymphoma
Volume51
Issue number11
DOIs
StatePublished - Nov 2010

Bibliographical note

Funding Information:
Declaration of interest: This work was supported by grant DOH99-TD-C-111-005 from Department of Health, Executive Yuan, R.O.C. (Taiwan).

Keywords

  • CHM-1
  • Invivo
  • leukemia WEHI-3 cells
  • leukemia murine model

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