Mechanical properties of pharmaceutical materials, e.g., Young's modulus (E), indentation hardness (H), and tensile strength (σt), play an important role in powder compaction process. However, few studies investigated the relationship among these parameters and consequence for tablet compression. Using microcrystalline cellulose, a plastic material, and dibasic calcium phosphate anhydrate, a brittle material, as well as their binary mixtures, we systematically examined the relationship among the three properties. It was found that Young's modulus was proportional to indentation hardness (H/E ≈ 0.036) regardless of the composition and compaction pressure. For a given material, tensile strength was also proportional to E and H but the relationship varied with materials. Higher E and H were required to attain the same σt for a more brittle material.
Bibliographical noteFunding Information:
This work was supported by a grant from Dane O. Kildsig Center for Pharmaceutical Processing Research (CPPR). W-J. Sun is grateful to the Department of Pharmaceutics, University of Minnesota for a David and Marilyn Grant Fellowship in Physical Pharmacy (2015-2017).
- Dibasic calcium phosphate
- Mechanical property
- Microcrystalline cellulose
- Tensile strength
- Young's modulus