The role of ATP and glucose 6-phosphate in the regulation of glycogen synthetase D phosphatase

Daniel P. Gilboe, frank q Nuttall

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Glycogen synthetase D phosphatase catalyzes the conversion of synthetase D to synthetase I. The phosphatase reaction has been found to be inhibited by ATP, ADP and UDP; however, only ATP inhibited at a physiological concentration. ATP inhibition was enhanced by glycogen. Glucose 6-phosphate (G 6-P) stimulated the phosphatase reaction and at least partially relieved the ATP inhibition. A possible physiological role for ATP, G 6-P and glycogen in the regulation of the synthetase D phosphatase reaction has been proposed.

Original languageEnglish (US)
Pages (from-to)898-906
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume48
Issue number4
DOIs
StatePublished - Aug 21 1972

Bibliographical note

Funding Information:
thanks to Mrs. Carol Reynolds This work supported in part by

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'The role of ATP and glucose 6-phosphate in the regulation of glycogen synthetase D phosphatase'. Together they form a unique fingerprint.

Cite this