Glycogen synthetase D phosphatase catalyzes the conversion of synthetase D to synthetase I. The phosphatase reaction has been found to be inhibited by ATP, ADP and UDP; however, only ATP inhibited at a physiological concentration. ATP inhibition was enhanced by glycogen. Glucose 6-phosphate (G 6-P) stimulated the phosphatase reaction and at least partially relieved the ATP inhibition. A possible physiological role for ATP, G 6-P and glycogen in the regulation of the synthetase D phosphatase reaction has been proposed.
|Original language||English (US)|
|Number of pages||9|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Aug 21 1972|
Bibliographical noteFunding Information:
thanks to Mrs. Carol Reynolds This work supported in part by
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