The role of cerebellar genes in pathology of autism and schizophrenia

S H Fatemi, Teri J. Reutiman, Timothy D. Folsom, Robert W. Sidwell

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Schizophrenia and autism are neurodevelopmental diseases that have genetic as well as environmental etiologies. Both disorders have been associated with prenatal viral infection. Brain imaging and postmortem studies have found alterations in the structure of the cerebellum as well as changes in gene expression. Our laboratory has developed an animal model using prenatal infection of mice with human influenza virus that has demonstrated changes in behavior, pharmacology, structure, and gene expression in the brains of exposed offspring. In the current communication we describe altered expression of cerebellar genes associated with development of brain disorder in a mouse model for schizophrenia and autism and correlate these changes with those involved in the pathology of these two disorders.

Original languageEnglish (US)
Pages (from-to)279-294
Number of pages16
JournalCerebellum
Volume7
Issue number3
DOIs
StatePublished - Sep 2008

Bibliographical note

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • Cerebellar
  • Gene
  • Infection
  • Psychiatric

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