The role of clusterin in tissue injury.

J. R. Silkensen, G. B. Schwochau, M. E. Rosenberg

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Clusterin is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. The expression of clusterin in these states is intriguing given the apparent incongruity of the conditions listed, the variety of stimuli eliciting such expression, and the multiple proposed roles once induced. This review will outline the conditions associated with clusterin induction and speculate on its role in disease.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalBiochemistry and cell biology = Biochimie et biologie cellulaire
Volume72
Issue number11-12
DOIs
StatePublished - 1994

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