The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

Jacob D. Estes; Ashley T. Haase; Timothy W. Schacker

doi:10.1016/j.smim.2008.04.002

The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

Jacob D. Estes, Ashley T. Haase, Timothy W. Schacker

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.

Original language	English (US)
Pages (from-to)	181-186
Number of pages	6
Journal	Seminars in Immunology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2008.04.002
State	Published - Jun 2008

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health grants R01 AI48484 and AI056997 to A.T.H., T32 AI07421 to J.D.E., and Public Health P130-CA79458-01, 1RO1DE12934-01, MO1 RR00400, 2UO1 AI041535, RO1 AI54232-01A2, and R37 AI 28246. This project has also been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Keywords

Fibrosis
HIV pathogenesis
Immune reconstitution
Lymphatic tissues
Naive CD4 cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche",

abstract = "The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.",

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note = "Funding Information: This work was supported by National Institutes of Health grants R01 AI48484 and AI056997 to A.T.H., T32 AI07421 to J.D.E., and Public Health P130-CA79458-01, 1RO1DE12934-01, MO1 RR00400, 2UO1 AI041535, RO1 AI54232-01A2, and R37 AI 28246. This project has also been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. ",

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N1 - Funding Information: This work was supported by National Institutes of Health grants R01 AI48484 and AI056997 to A.T.H., T32 AI07421 to J.D.E., and Public Health P130-CA79458-01, 1RO1DE12934-01, MO1 RR00400, 2UO1 AI041535, RO1 AI54232-01A2, and R37 AI 28246. This project has also been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

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N2 - The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.

AB - The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.

KW - Fibrosis

KW - HIV pathogenesis

KW - Immune reconstitution

KW - Lymphatic tissues

KW - Naive CD4 cells

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The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

Abstract

Bibliographical note

Keywords

UN SDGs

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