The Role of Redox Cycling Versus Arylation in Quinone-Induced Mitochondrial Dysfunction: A Mechanistic Approach in Classifying Reactive Toxicants

Medicine & Life Sciences

• 1,4-naphthoquinone 74%
• quinone 66%
• Oxidation-Reduction 52%
• 2,3-dimethyl-1,4-naphthoquinone 48%
• Quinones 47%
• Cyclosporine 30%
• 2,3-dimethoxy-1,4-naphthoquinone 20%
• Vitamin K 3 15%
• Mitochondrial Membranes 12%
• Membrane Potentials 10%
• Electrons 8%
• Calcium 7%
• Membranes 6%

Chemical Compounds

• 1,4-naphthoquinone 74%
• Arylation 59%
• 1,4-benzoquinone 55%
• Quinone 52%
• Electrophilicity 16%
• Depolarization 15%
• Membrane Potential 14%
• Reduction Potential 14%
• Permeability 10%
• Calcium(0) 10%
• Electron Particle 7%

Engineering & Materials Science

• Quinone 100%
• Oxidation-Reduction 71%
• Membranes 27%
• Depolarization 15%
• Toxicity 12%
• Swelling 12%
• Calcium 11%
• Electrons 10%
• Fluxes 8%