The Role of TGF—β Signaling in Cardiomyocyte Proliferation

Daniel W. Sorensen, Jop H. van Berlo

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: The loss of contractile function after heart injury remains one of the major healthcare issues of our time. One strategy to deal with this problem would be to increase the number of cardiomyocytes to enhance cardiac function. In the last couple of years, reactivation of cardiomyocyte proliferation has repeatedly demonstrated to aid in functional recovery after cardiac injury. Recent Findings: The Tgf-β superfamily plays key roles during development of the heart and populating the embryonic heart with cardiomyocytes. In this review, we discuss the role of Tgf-β signaling in regulating cardiomyocyte proliferation during development and in the setting of cardiac regeneration. Summary: Although various pathways to induce cardiomyocyte proliferation have been established, the extent to which cardiomyocyte proliferation requires or involves activation of the Tgf-β superfamily is not entirely clear. More research is needed to better understand cross-talk between pathways that regulate cardiomyocyte proliferation.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalCurrent Heart Failure Reports
Volume17
Issue number5
DOIs
StatePublished - Oct 1 2020

Bibliographical note

Funding Information:
DWS is supported by National Institutes of Health grant T32GM113846, and JHvB is supported by NIH (HL130072), Regenerative Medicine Minnesota (RMM102516-009), and an Individual Biomedical Research Scholarship from The Hartwell Foundation. Illustrations were provided by L. Sorensen.

Funding Information:
DWS is supported by National Institutes of Health grant T32GM113846, and JHvB is supported by NIH (HL130072), Regenerative Medicine Minnesota (RMM102516-009), and an Individual Biomedical Research Scholarship from The Hartwell Foundation. Illustrations were provided by L. Sorensen.

Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Cardiac regeneration
  • Heart
  • Proliferation
  • TGF-β signaling

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

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