The role of the glomerular epithelial cell in the maintenance of the glomerular filtration barrier

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Abstract

Glomerular epithelial cells contribute significantly to the hydraulic and macromolecular permeability properties of the glomerulus. Because of their location as the terminal element in the filtration barrier and their elaborate cyto- skeleton, they are likely to participate in the regulation of filtration. In disease, alterations of the glomerular epithelial cells may lead to simplification and retraction of foot processes, resulting in a decreased density of slit diaphragms and decreased by hydraulic conductivity. In addition, denudation of epithelial cells from the basement membrane results in increased macromolecular permeability at those sites and accounts for much of the proteinuria in a variety of types of renal disease.

Original languageEnglish (US)
Pages (from-to)318-323
Number of pages6
JournalAmerican Journal of Nephrology
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1993

Keywords

  • Filtration barrier
  • Glomerular epithelial cells
  • Proteinuria

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