The role of vitamin D in hematologic disease and stem cell transplantation

Aric C. Hall, Mark B. Juckett

Research output: Contribution to journalReview articlepeer-review

Abstract

Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant.

Original languageEnglish (US)
Pages (from-to)2206-2221
Number of pages16
JournalNutrients
Volume5
Issue number6
DOIs
StatePublished - Jun 18 2013
Externally publishedYes

Keywords

  • Acute leukemia
  • Allogeneic stem cell transplant
  • Differentiation therapy
  • Vitamin D

Fingerprint

Dive into the research topics of 'The role of vitamin D in hematologic disease and stem cell transplantation'. Together they form a unique fingerprint.

Cite this