The salivary pellicle on dental biomaterials

Nicholas G. Fischer, Conrado Aparicio

Research output: Contribution to journalReview articlepeer-review


The salivary pellicle, an adlayer formed by adsorption of salivary components on teeth and dental biomaterials, has direct consequences on basic outcomes of dentistry. Here, we provide an overview of salivary pellicle formation processes with a critical focus on dental biomaterials. We describe and critique the array of salivary pellicle measurement techniques. We also discuss factors that may affect salivary pellicle formation and the heterogeneity of the published literature describing salivary pellicle formation on dental biomaterials. Finally, we survey the many effects salivary pellicles have on dental biomaterials and highlight its implications on design criteria for dental biomaterials. Future investigations may lead to rationally designed dental biomaterials to control the salivary pellicle and enhance material function and patient outcomes.

Original languageEnglish (US)
Article number111570
JournalColloids and Surfaces B: Biointerfaces
StatePublished - Apr 2021

Bibliographical note

Funding Information:
NGF acknowledges support from NIH-NIDCR T90-DE0227232 and a 3M Science and Technology Fellowship . This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.


  • Dental biomaterials
  • Dentistry
  • Protein adsorption
  • Salivary pellicle
  • Surface

PubMed: MeSH publication types

  • Journal Article
  • Review

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