The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions

Yongjun Liu, Jose M. Ordovas, Guimin Gao, Michael Province, Robert J. Straka, Michael Y. Tsai, Chao Qiang Lai, Kui Zhang, Ingrid Borecki, James E. Hixson, David B. Allison, Donna K. Arnett

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The scavenger receptor class B type 1 (SCARB1) gene is a key component in the reverse cholesterol transport pathway and thus plays an important role in lipid metabolism. Studies suggest that the SCARB1 gene may contribute to variation in plasma lipid levels at fasting; however, the results have been inconsistent, and it is unclear whether SCARB1 may also influence lipid response to dietary and pharmacologic interventions. In this study, we examined genetic variation in the SCARB1 gene in participants of the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study for associations with basal lipid levels, changes in lipid measures after dietary fat intake, and fenofibrate treatment. We found that the exon 1 variant SCARB1_G2S was significantly associated with postfenofibrate change for triglycerides (TG) (P = 0.004). Subjects bearing SCARB1_G2S minor allele A tend to have higher responsiveness to fenofibrate in lowering TG. In summary, our study suggested that the SCARB1 gene may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention.

Original languageEnglish (US)
Pages (from-to)709-717
Number of pages9
JournalJournal of Human Genetics
Volume53
Issue number8
DOIs
StatePublished - Aug 2008

Keywords

  • Fenofibrate
  • Genetics
  • Lipid
  • Postprandial
  • Scavenger receptor class B type 1

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