The significance of siglec-15 expression in resectable non-small cell lung cancer

J. Q. Hao, J. Y. Nong, D. Zhao, H. Y. Li, D. Su, L. J. Zhou, Y. J. Dong, C. Zhang, N. Y. Che, S. C. Zhang, J. Z. Lin, J. B. Yang, H. T. Zhang, J. H. Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Siglec-15 (S15) is another important mechanism of tumor immune escape besides the PD-L1/PD-1 pathway and repre-sents a new kind of immune checkpoint inhibitor. However, the associations of tumor Siglec-15 expression with clinicopath-ological characteristics and outcomes of non-small cell lung cancer (NSCLC), and tumor-infiltrating lymphocytes (TILs) in a tumor microenvironment (TME) have so far been unclear. A total of 324 NSCLC surgical samples on tumor microarray were used in this study for investigating the association of S15 expression with clinicopathological characteristics and overall survival (OS) as well as correlation with TILs using multiplex immunofluorescence staining and PD-L1. Results showed that the expression of S15 in adenocarcinoma was significantly higher than that in squamous cell carcinoma. S15 expression was positively correlated with CD8+ T cell density in the stroma. The expression rate of PD-L1 in lung squamous cell carcinoma was higher than that in lung adenocarcinoma. S15 expression was not associated with the prognosis of early NSCLC. The pathological mechanism of the co-expression of S15 and PD-L1 in resectable NSCLC remains to be further studied.

Original languageEnglish (US)
Pages (from-to)1214-1222
Number of pages9
JournalNeoplasma
Volume67
Issue number6
DOIs
StatePublished - 2020

Bibliographical note

Funding Information:
Acknowledgments: We thank other colleagues and members in the Department of Pathology and Laboratories of Beijing Chest Hospital for experiment assistance. This study was supported by the Lung Cancer Project from Beijing Municipal Health Commission 362 (2017–2019).

Funding Information:
We thank other colleagues and members in the Department of Pathology and Laboratories of Beijing Chest Hospital for experiment assistance. This study was supported by the Lung Cancer Project from Beijing Municipal Health Commission 362 (2017?2019).

Publisher Copyright:
© 2020, AEPress, s.r.o. All rights reserved.

Keywords

  • Multiplex immunofluorescence staining
  • NSCLC
  • Siglec-15
  • TILs

PubMed: MeSH publication types

  • Journal Article

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