Abstract
The analysis of powder compressibility data yields useful information for characterizing compaction behavior and mechanical properties of powders, especially plasticity. Among the many compressibility equations proposed in powder compaction research, the Heckel equation and the Kawakita equation are the most commonly used, despite their known limitations. Systematic evaluation of the performance in analyzing compressibility data suggested the Kuentz-Leuenberger equation is superior to both the Heckel equation and the Kawakita equation for characterizing plasticity of powders exhibiting a wide range of mechanical properties.
Original language | English (US) |
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Pages (from-to) | 124-130 |
Number of pages | 7 |
Journal | International journal of pharmaceutics |
Volume | 532 |
Issue number | 1 |
DOIs | |
State | Published - Oct 30 2017 |
Keywords
- Compressibility
- Hardness
- Heckel equation
- Kawakita equation
- Kuentz-Leuenberger equation
- Plasticity
- Tableting