Abstract
The strength with which complexes of self peptide and major histocompatibility complex (MHC) proteins are recognized by the T cell antigen receptor (TCR) dictates the homeostasis of naive CD8+ T cells, but its effect on reactivity to foreign antigens is controversial. As expression of the negative regulator CD5 correlates with self-recognition, we studied CD5lo and CD5hinaive CD8+ T cells. Gene-expression characteristics suggested CD5 hi cells were better poised for reactivity and differentiation than were CD5lo cells, and we found that the CD5hi pool also exhibited more efficient clonal recruitment and expansion, as well as enhanced reactivity to inflammatory cues, during the recognition of foreign antigen. However, the recognition of complexes of foreign peptide and MHC was similar for both subsets. Thus, CD8 + T cells with higher self-reactivity dominate the immune response to foreign antigens, with implications for T cell repertoire diversity and autoimmunity.
Original language | English (US) |
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Pages (from-to) | 107-117 |
Number of pages | 11 |
Journal | Nature immunology |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Dec 18 2015 |
Bibliographical note
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