The therapeutic potential of embryonic and adult stem cells for skeletal muscle regeneration

Radbod Darabi, Filipe N C Santos, Rita C R Perlingeiro

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Muscular dystrophy (MD) refers to a group of more than 30 genetically and clinically heterogeneous disorders, characterized by progressive weakness and degeneration of the skeletal muscles that control movement. To date, MD is still incurable but increasing evidence suggests that stem cells might represent a therapeutic option in the future. This review will outline recent progress in this field involving the use of adult and embryonic stem cells. We will discuss in further detail the nature of these cells and their distinct biological properties which lead to their unique advantages and disadvantages in regard to therapeutic application.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalStem Cell Reviews
Volume4
Issue number3
DOIs
StatePublished - Sep 2008

Bibliographical note

Funding Information:
Acknowledgments This work was supported by the Dr. Bob and Jean Smith Foundation.

Keywords

  • Adult stem cells
  • Cell therapy
  • Embryonic stem cells
  • Muscle regeneration
  • Muscular dystrophy
  • Myogenesis
  • Pax3

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