The Thrsp null mouse (Thrsptm1cnm) and diet-induced obesity

Grant W Anderson, Qihong Zhu, Jennifer Metkowski, Mary Jo Stack, Sunil Gopinath, Cary N. Mariash

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We created a Thrsp (Spot 14 or S14) null mouse (Thrsptm1cnm) to study the role of Thrsp in de novo lipid synthesis. The Thrsp null mouse exhibits marked deficiencies in de novo lipogenesis in the lactating mammary gland. We now report the Thrsp gene deletion affects body weight and glucose tolerance associated with increased insulin sensitivity. By post-natal day 150 the rate of first generation C57BL/6J backcross Thrsp null mouse weight gain slowed compared to wild type animals. This was due to changes in body fat mass. We studied mice backcrossed for 5 and 11 generations. The weight difference between the null and wild type adult mice diminished with progressive backcross generations. In conclusion the Thrsp gene is involved in the regulation of diet-induced obesity and deletion of Thrsp leads to an improvement in age associated glucose tolerance.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalMolecular and Cellular Endocrinology
Issue number1
StatePublished - Apr 10 2009

Bibliographical note

Funding Information:
This work was supported, in part, by NIH P30-DK50456 and T32-DK007203.


  • Glucose tolerance
  • Insulin sensitivity
  • Obesity
  • Spot 14

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