The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies

Hirotaka Tao; Yasuhiko Kawakami; Chi Chung Hui; Sevan Hopyan

doi:10.1002/wdev.270

The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies

Hirotaka Tao, Yasuhiko Kawakami, Chi Chung Hui, Sevan Hopyan

Genetics, Cell Biology and Development (TMED)

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270. For further resources related to this article, please visit the WIREs website.

Original language	English (US)
Article number	e270
Journal	Wiley Interdisciplinary Reviews: Developmental Biology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1002/wdev.270
State	Published - Jul 1 2017

Bibliographical note

Funding Information:
This work was supported by a CIHR grant to S.H. and C-c.H (137092) and an NIH grant to Y.K. (AR064195).

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

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10.1002/wdev.270

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679199

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title = "The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies",

abstract = "Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270. For further resources related to this article, please visit the WIREs website.",

author = "Hirotaka Tao and Yasuhiko Kawakami and Hui, {Chi Chung} and Sevan Hopyan",

note = "Funding Information: This work was supported by a CIHR grant to S.H. and C-c.H (137092) and an NIH grant to Y.K. (AR064195). Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

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AU - Hui, Chi Chung

AU - Hopyan, Sevan

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AB - Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270. For further resources related to this article, please visit the WIREs website.

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The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies

Abstract

Bibliographical note

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