The University of Minnesota Biocatalysis/Biodegradation Database: Specialized metabolism for functional genomics

Lynda B.M. Ellis, C. Douglas Hershberger, Lawrence P. Wackett

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations

Abstract

The University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD, http://www.labmed.umn.edu/umbbd/index.html) first became available on the web in 1995 to provide information on microbial biocatalytic reactions of, and biodegradation pathways for, organic chemical compounds, especially those produced by man. Its goal is to become a representative database of biodegradation, spanning the diversity of known microbial metabolic routes, organic functional groups, and environmental conditions under which biodegradation occurs. The database can be used to enhance understanding of basic biochemistry, biocatalysis leading to speciality chemical manufacture, and biodegradation of environmental pollutants. It is also a resource for functional genomics, since it contains information on enzymes and genes involved in specialized metabolism not found in intermediary metabolism databases, and thus can assist in assigning functions to genes homologous to such less common genes. With information on > 400 reactions and compounds, it is poised to become a resource for prediction of microbial biodegradation pathways for compounds it does not contain, a process complementary to predicting the functions of new classes of microbial gene.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalNucleic acids research
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1999

Bibliographical note

Funding Information:
We thank Jingfeng Feng and Stuart Speedie for helpful discussions. This work was supported in part by National Science Foundation Award 9630427, National Institutes of Health Award R01-GM56529 and an NIH Training Grant LM07041 traineeship to C.D.H.

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