Bioassay and immunoassay techniques for the measurement of ACTH in human plasma have provided sensitive and specific results but have also met with some skepticism as to their reliability in some clinical circumstances. The recent development of a supersensitive two-site immunoradiometric assay for ACTH may resolve sole of the limitations of previous assays and greatly facilitate the evaluation of pituitary-adrenal disorders.
Bibliographical noteFunding Information:
The studies described were supported in part by grants from the St. Luke’s Foundation to H.R. and DK38951 to W.C.E.
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