The use of polymer-bound triphenylphosphine in the stereochemical inversion of secondary alcohols

J. M. White, A. R. Tunoori, D. Dutta, G. I. Georg

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Polymer-bound triphenylphosphine can replace triphenylphosphine in the Mitsunobu reaction to generate stereochemically inverted secondary alcohols. This method is comparable with the standard Mitsunobu reaction in terms of inversion of stereochemistry, yield, and reaction time, even for sterically very hindered secondary alcohols. The special merit of this reaction is that the excess polymer-bound triphenylphosphine and its by-products are easily removed by filtration from the reaction products.

Original languageEnglish (US)
Pages (from-to)103-106
Number of pages4
JournalCombinatorial Chemistry and High Throughput Screening
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2000

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