The utility of information content, structural information content, hydrophobicity and van der Waals volume in the design of barbiturates and tumor inhibitory triazenes. A comparative study

S. K. Ray, S. C. Basak, C. Raychaudhury, A. B. Roy, J. J. Ghosh

Research output: Contribution to journalArticlepeer-review

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Abstract

In this paper a comparative study of hydrophobicity (log P), Van der Waals volume (V(w)), information content (IC) and structural information content (SIC) in the correlation of the pharmacological potencies of barbiturates and triazenes is undertaken. Results show that the topological indices are superior to hydrophobicity (log P) and van der Waals volume (V(w)) in rationalizing biological action of the congeners.

Original languageEnglish (US)
Pages (from-to)352-356
Number of pages5
JournalArzneimittel-Forschung/Drug Research
Volume33
Issue number3
StatePublished - Apr 14 1983

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