The utility of information content, structural information content, hydrophobicity and van der Waals volume in the design of barbiturates and tumor inhibitory triazenes. A comparative study

S. K. Ray; S. C. Basak; C. Raychaudhury; A. B. Roy; J. J. Ghosh

The utility of information content, structural information content, hydrophobicity and van der Waals volume in the design of barbiturates and tumor inhibitory triazenes. A comparative study

S. K. Ray, S. C. Basak, C. Raychaudhury, A. B. Roy, J. J. Ghosh

Natural Resources Research Institute

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Abstract

In this paper a comparative study of hydrophobicity (log P), Van der Waals volume (V(w)), information content (IC) and structural information content (SIC) in the correlation of the pharmacological potencies of barbiturates and triazenes is undertaken. Results show that the topological indices are superior to hydrophobicity (log P) and van der Waals volume (V(w)) in rationalizing biological action of the congeners.

Original language	English (US)
Pages (from-to)	352-356
Number of pages	5
Journal	Arzneimittel-Forschung/Drug Research
Volume	33
Issue number	3
State	Published - Apr 14 1983

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The utility of information content, structural information content, hydrophobicity and van der Waals volume in the design of barbiturates and tumor inhibitory triazenes. A comparative study. / Ray, S. K.; Basak, S. C.; Raychaudhury, C. et al.
In: Arzneimittel-Forschung/Drug Research, Vol. 33, No. 3, 14.04.1983, p. 352-356.

Research output: Contribution to journal › Article › peer-review

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The utility of information content, structural information content, hydrophobicity and van der Waals volume in the design of barbiturates and tumor inhibitory triazenes. A comparative study

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