Abstract
Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4+ T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologie or immunologic benefit.
Original language | English (US) |
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Pages (from-to) | 1298-1302 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 201 |
Issue number | 9 |
DOIs | |
State | Published - May 1 2010 |