Thermodynamics and kinetics of a molecular motor ensemble

Josh E. Baker, David D. Thomas

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

If, contrary to conventional models of muscle, it is assumed that molecular forces equilibrate among rather than within molecular motors, an equation of state and an expression for energy output can be obtained for a near-equilibrium, coworking ensemble of molecular motors. These equations predict clear, testable relationships between motor structure, motor biochemistry, and ensemble motor function, and we discuss these relationships in the context of various experimental studies. In this model, net work by molecular motors is performed with the relaxation of a near-equilibrium intermediate step in a motor-catalyzed reaction. The free energy available for work is localized to this step, and the rate at which this free energy is transferred to work is accelerated by the free energy of a motor-catalyzed reaction. This thermodynamic model implicitly deals with a motile cell system as a dynamic network (not a rigid lattice) of molecular motors within which the mechanochemistry of one motor influences and is influenced by the mechanochemistry of other motors in the ensemble.

Original languageEnglish (US)
Pages (from-to)1731-1736
Number of pages6
JournalBiophysical journal
Volume79
Issue number4
DOIs
StatePublished - 2000

Bibliographical note

Funding Information:
We thank E. de la Cruz, L. E. W. LaConte, J. R. Moore, K. A. Palmiter, M. J. Tyska, and D. M. Warshaw for helpful discussions. This work was supported by the National Institutes of Health (AR32961).

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