Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review

L. S. Goettsche; M. S. Moye; A. J. Tschetter; M. S. Stone; K. A. Wanat

doi:10.1016/j.ijwd.2016.11.003

Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review

L. S. Goettsche, M. S. Moye, A. J. Tschetter, M. S. Stone, K. A. Wanat

Dermatology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis. In patients with LCNA, local plasma cells secrete immunoglobulin light chains called amyloid L via an unknown mechanism. LCNA has been associated with autoimmune connective tissue diseases such as most commonly Sjögren syndrome. A few reported cases of LCNA are associated with limited systemic sclerosis (LSSc). We report three cases of LCNA in patients with LSSc to add to the existing literature, discuss the disease association and proposed pathophysiology, and briefly review the existing information in current literature. It is important to closely follow patients with LCNA to monitor progression to systemic amyloidosis.

Original language	English (US)
Pages (from-to)	91-95
Number of pages	5
Journal	International Journal of Women's Dermatology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.ijwd.2016.11.003
State	Published - Jun 2017

Bibliographical note

Publisher Copyright:
© 2016 The Author(s)

Keywords

connective tissue disease
histopathology
limited systemic sclerosis
nodular amyloidosis

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10.1016/j.ijwd.2016.11.003

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440445

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abstract = "Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis. In patients with LCNA, local plasma cells secrete immunoglobulin light chains called amyloid L via an unknown mechanism. LCNA has been associated with autoimmune connective tissue diseases such as most commonly Sj{\"o}gren syndrome. A few reported cases of LCNA are associated with limited systemic sclerosis (LSSc). We report three cases of LCNA in patients with LSSc to add to the existing literature, discuss the disease association and proposed pathophysiology, and briefly review the existing information in current literature. It is important to closely follow patients with LCNA to monitor progression to systemic amyloidosis.",

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AU - Stone, M. S.

AU - Wanat, K. A.

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Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review

Abstract

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