A dual-mode ultrasound array (DMUA) imaging system for monitoring and delivery of transcranial focused ultrasound (tFUS) therapy is described. A DMUA prototype operating in the frequency range 2.4 - 4.2 MHz has been shown to generate tFUS beams at therapeutic levels in rat brains in vivo based on two-dimensional image guidance. Furthermore, real-time ultrasound thermography was shown to be feasible using beamformed DMUA imaging data. In this paper, we demonstrate the use of 3D DMUA imaging for guidance of tFUS beam to specific locations within the brain defined with reference to the bregma. The results demonstrate the ability of the DMUA prototype to clearly resolve the lambda, bregma and the medial suture lines, which allows the precise placement of the focal spot at the target location in a repeatable manner within a single experiment session and from one session to another. This has significant impact on tFUS applications requiring multiple treatments of the same target region, e.g. temporal lobe epilepsy.
|Original language||English (US)|
|Title of host publication||2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017|
|Publisher||IEEE Computer Society|
|Number of pages||4|
|State||Published - Jun 15 2017|
|Event||14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia|
Duration: Apr 18 2017 → Apr 21 2017
|Name||Proceedings - International Symposium on Biomedical Imaging|
|Other||14th IEEE International Symposium on Biomedical Imaging, ISBI 2017|
|Period||4/18/17 → 4/21/17|
Bibliographical noteFunding Information:
NIH Grants NS098781 and NS087887.
© 2017 IEEE.
Copyright 2017 Elsevier B.V., All rights reserved.
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