Three-dimensional image guidance for transcranial focused ultrasound therapy

Dalong Liu; Kyle Schaible; Walter Low; Emad S. Ebbini

doi:10.1109/ISBI.2017.7950665

Three-dimensional image guidance for transcranial focused ultrasound therapy

Dalong Liu, Kyle Schaible, Walter Low, Emad S. Ebbini

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

A dual-mode ultrasound array (DMUA) imaging system for monitoring and delivery of transcranial focused ultrasound (tFUS) therapy is described. A DMUA prototype operating in the frequency range 2.4 - 4.2 MHz has been shown to generate tFUS beams at therapeutic levels in rat brains in vivo based on two-dimensional image guidance. Furthermore, real-time ultrasound thermography was shown to be feasible using beamformed DMUA imaging data. In this paper, we demonstrate the use of 3D DMUA imaging for guidance of tFUS beam to specific locations within the brain defined with reference to the bregma. The results demonstrate the ability of the DMUA prototype to clearly resolve the lambda, bregma and the medial suture lines, which allows the precise placement of the focal spot at the target location in a repeatable manner within a single experiment session and from one session to another. This has significant impact on tFUS applications requiring multiple treatments of the same target region, e.g. temporal lobe epilepsy.

Original language	English (US)
Title of host publication	2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017
Publisher	IEEE Computer Society
Pages	916-919
Number of pages	4
ISBN (Electronic)	9781509011711
DOIs	https://doi.org/10.1109/ISBI.2017.7950665
State	Published - Jun 15 2017
Event	14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia Duration: Apr 18 2017 → Apr 21 2017

Publication series

Name	Proceedings - International Symposium on Biomedical Imaging
ISSN (Print)	1945-7928
ISSN (Electronic)	1945-8452

Other

Other	14th IEEE International Symposium on Biomedical Imaging, ISBI 2017
Country/Territory	Australia
City	Melbourne
Period	4/18/17 → 4/21/17

Bibliographical note

Funding Information:
NIH Grants NS098781 and NS087887.

Publisher Copyright:
© 2017 IEEE.

Keywords

Beamforming
Image-guided surgery
Neuromodulation
Synthetic-aperture Imaging
Ultrasound Thermography

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10.1109/ISBI.2017.7950665

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Cite this

Three-dimensional image guidance for transcranial focused ultrasound therapy. / Liu, Dalong; Schaible, Kyle; Low, Walter et al.
2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017. IEEE Computer Society, 2017. p. 916-919 7950665 (Proceedings - International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liu, D, Schaible, K, Low, W & Ebbini, ES 2017, Three-dimensional image guidance for transcranial focused ultrasound therapy. in 2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017., 7950665, Proceedings - International Symposium on Biomedical Imaging, IEEE Computer Society, pp. 916-919, 14th IEEE International Symposium on Biomedical Imaging, ISBI 2017, Melbourne, Australia, 4/18/17. https://doi.org/10.1109/ISBI.2017.7950665

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author = "Dalong Liu and Kyle Schaible and Walter Low and Ebbini, {Emad S.}",

note = "Funding Information: NIH Grants NS098781 and NS087887. Publisher Copyright: {\textcopyright} 2017 IEEE.; 14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 ; Conference date: 18-04-2017 Through 21-04-2017",

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Three-dimensional image guidance for transcranial focused ultrasound therapy

Abstract

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Bibliographical note

Keywords

Access

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